Description

Boc-D-1,2,3,4-Tetrahydronorharman-3-Carboxylic Acid is a protected amino acid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical chiral building block for the synthesis of complex molecules, particularly in the field of medicinal chemistry. It is primarily utilized by R&D chemists and process development scientists in pharmaceutical, biotechnology, and fine chemical industries for constructing novel drug candidates and bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex active pharmaceutical ingredients (APIs) and drug candidates.
• Peptidomimetics Research: Used in the design and construction of peptidomimetics and constrained peptides to modulate biological activity and stability.
• Medicinal Chemistry: Serves as a versatile building block for creating focused libraries and novel molecular scaffolds in drug discovery programs.
• Asymmetric Synthesis: Employed in stereoselective synthesis due to its chiral center, enabling the production of enantiomerically pure compounds.
• Bioconjugation & Probe Development: Useful for creating labeled compounds or probes for biochemical and pharmacological studies.
• Fine Chemical Synthesis: Applied in the multi-step synthesis of specialty chemicals and advanced materials requiring high stereochemical purity.

Basic Information

Product Name	Boc-D-1,2,3,4-Tetrahydronorharman-3-Carboxylic Acid
CAS No.	123910-26-9
Molecular Formula	C₁₇H₂₀N₂O₄
Molecular Weight	316.35 g/mol
Synonyms	(R)-1-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid; Boc-D-Tic-OH (Tetrahydroisoquinoline carboxylic acid derivative); tert-Butyl (R)-1,2,3,4-tetrahydro-3-carboxy-9H-pyrido[3,4-b]indole-1-carboxylate; D-Boc-1,2,3,4-Tetrahydro-norharman-3-carboxylic acid; Boc-D-β-Carboline-3-carboxylic acid (tetrahydro); (R)-1-Boc-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid; (R)-N-Boc-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our Boc-D-1,2,3,4-Tetrahydronorharman-3-Carboxylic Acid is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. Certificates of Analysis (COA) are provided with each batch, detailing key parameters such as chiral purity, chemical purity, and identity confirmation. We adhere to cGMP guidelines where applicable to support our customers' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.