Description

Nh-(m-Peg4)2 CAS NO 123852-08-4 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a central amine group and two methoxy-terminated tetraethylene glycol (m-PEG4) arms. This unique structure makes it a critical intermediate for the synthesis of sophisticated bioconjugates, enabling precise control over solubility, pharmacokinetics, and molecular spacing. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for applications such as drug delivery system development, protein and peptide modification, and surface functionalization.

Application

• Bioconjugation Linker: Serves as a versatile spacer and linker for attaching drugs, dyes, or targeting ligands to antibodies, proteins, and nanoparticles.
• PEGylation Reagent: Used to modify therapeutic peptides and proteins to enhance solubility, reduce immunogenicity, and prolong circulation half-life.
• Drug Delivery Systems: A key building block in the construction of prodrugs, dendrimers, and polymer-drug conjugates for controlled release.
• Surface Modification: Functionalizes surfaces (e.g., gold nanoparticles, quantum dots, biosensors) to improve biocompatibility and reduce non-specific binding.
• Crosslinking Agent: Utilized in hydrogel formation and material science for creating networks with specific mechanical and release properties.
• Diagnostic Probe Synthesis: Facilitates the development of imaging agents and diagnostic probes by providing a hydrophilic PEG spacer.

Basic Information

Product Name	Nh-(m-Peg4)2 CAS NO 123852-08-4
CAS No.	123852-08-4
Molecular Formula	C21H45NO10
Molecular Weight	471.59 g/mol
Synonyms	1-Amino-3,6,9,12-tetraoxapentadecan-15-ol; 15-Amino-4,7,10,13-tetraoxapentadecan-1-ol; m-PEG4-Amine (bis); 2,2'-(2-(2-(2-Methoxyethoxy)ethoxy)ethylazanediyl)bis(ethan-1-ol); NH2-PEG4-OH (bis-methoxy); Heterobifunctional PEG Amine; Amino-PEG4-alcohol; 1,11-Diamino-3,6,9-trioxaundecane derivative
EINECS	Contact for details

Quality Control

Our Nh-(m-Peg4)2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support cGMP-grade production for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. This product is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.