Description

1-Boc-1,2,3,4-Tetrahydro-Quinoline-2-Carboxylic Acid is a high-purity, protected amino acid derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of novel pharmaceuticals and bioactive compounds. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for applications in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of drug candidates, particularly those containing the tetrahydroquinoline scaffold.
• Peptidomimetics & PROTACs: Used in the construction of peptide analogs and Proteolysis Targeting Chimeras (PROTACs) for targeted protein degradation.
• Medicinal Chemistry Research: Serves as a versatile building block for structure-activity relationship (SAR) studies and library synthesis.
• Agrochemical Synthesis: Employed in the development of novel active ingredients for crop protection.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring chiral, protected intermediates.

Basic Information

Item	Detail
Product Name	1-Boc-1,2,3,4-Tetrahydro-Quinoline-2-Carboxylic Acid
CAS No.	123811-87-0
Molecular Formula	C15H19NO4
Molecular Weight	277.32 g/mol
Synonyms	1-[(1,1-Dimethylethoxy)carbonyl]-1,2,3,4-tetrahydro-2-quinolinecarboxylic acid; 1-Boc-1,2,3,4-tetrahydroquinoline-2-carboxylic acid; 2-Quinolinecarboxylic acid, 1,2,3,4-tetrahydro-1-[(1,1-dimethylethoxy)carbonyl]-; Boc-Tic-OH; tert-Butyl 2-carboxy-1,2,3,4-tetrahydroquinoline-1-carboxylate; 1-N-Boc-1,2,3,4-tetrahydroquinoline-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-Boc-1,2,3,4-Tetrahydro-Quinoline-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports applications requiring high standards, including cGMP-compliant production for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.