Description

4-(Methylnitrosamino)-4-(3-Pyridyl)Butyric Acid is a specialized nitrosamine compound of significant interest in analytical and research chemistry. This chemical serves as a crucial reference standard and analytical marker for the detection and quantification of tobacco-specific nitrosamines (TSNAs). It is primarily required by analytical laboratories, research institutions, and quality control departments within the pharmaceutical and tobacco industries for method development, validation, and regulatory compliance testing.

Application

• Analytical Reference Standard: Primary use as a certified reference material (CRM) for calibrating analytical instruments like HPLC, LC-MS, and GC-MS.
• Tobacco Research & Safety Testing: Critical for quantifying the presence of tobacco-specific nitrosamines (TSNAs) in tobacco products, smokeless tobacco, and cigarette smoke condensate.
• Pharmaceutical Impurity Testing: Used in method development to detect and control potentially genotoxic nitrosamine impurities (NTIs) in active pharmaceutical ingredients (APIs) and drug products, aligning with ICH M7 and regulatory guidelines.
• Biomarker Analysis: Employed in metabolic and pharmacokinetic studies to understand the biotransformation and excretion pathways of related nitrosamines.
• Food Safety Analysis: Applied in trace-level detection methods for nitrosamines in certain food products and beverages.
• Environmental Monitoring: Used as a standard in assays designed to monitor nitrosamine contamination in water and soil.
• Academic & Contract Research: Essential for universities and CROs conducting studies on carcinogenesis, DNA adduct formation, and chemical toxicology.

Basic Information

Product Name	4-(Methylnitrosamino)-4-(3-Pyridyl)Butyric Acid
CAS No.	123743-84-0
Molecular Formula	C10H13N3O3
Molecular Weight	223.23 g/mol
Synonyms	4-(Methylnitrosamino)-4-(3-pyridyl)butanoic acid; NNK Acid; 4-(N-Methyl-N-nitrosamino)-4-(3-pyridinyl)butyric acid; 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Acid; Iso-NNAC; 4-(Methylnitrosamino)-4-(3-pyridyl)butanoate; NNK Metabolite; 4-(3-Pyridyl)-4-(methylnitrosamino)butyric acid
EINECS	Contact for details

Quality Control

Our 4-(Methylnitrosamino)-4-(3-Pyridyl)Butyric Acid is manufactured and handled under strict quality management systems. Each batch undergoes rigorous identity confirmation, purity analysis, and stability testing to ensure it meets the high standards required for analytical and research applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/LC-MS) are provided, confirming lot-specific purity, typically ≥95% (by HPLC). We support compliance with pharmacopeial and ICH guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. For long-term storage, consider storing desiccated at -20°C. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.