Description

O1-(Dimethoxytrityl)Hexaethylene Glycol is a high-purity, monodisperse polyethylene glycol (PEG) derivative functionalized with a dimethoxytrityl (DMT) protecting group. This compound is a critical building block in the synthesis of oligonucleotides and other complex biomolecules, where it serves as a versatile spacer or linker. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require precise chemical tools for drug discovery, genetic analysis, and therapeutic development.

Application

• Oligonucleotide Synthesis: Primarily used as a hydrophilic spacer or linker in solid-phase phosphoramidite synthesis of DNA/RNA oligonucleotides.
• Probe and Primer Modification: Incorporation into fluorescent probes, primers, and other labeled nucleic acids to enhance solubility and reduce aggregation.
• Bioconjugation: Acts as a heterobifunctional crosslinker for attaching biomolecules (e.g., peptides, drugs) to surfaces, nanoparticles, or other macromolecules.
• Therapeutic Agent Development: Used in the creation of PEGylated therapeutics, aptamers, and antisense oligonucleotides to improve pharmacokinetic properties.
• Diagnostic Assays: Employed in the development of advanced diagnostic kits and biosensors that require stable, non-interfering molecular spacers.
• Materials Science: Serves as a functional monomer or initiator for creating specialized polymers with tailored hydrophilic properties.

Basic Information

Product Name	O1-(Dimethoxytrityl)Hexaethylene Glycol
CAS No.	123706-69-4
Molecular Formula	C35H48O9
Molecular Weight	612.75 g/mol
Synonyms	DMT-Hexaethylene Glycol; 1-O-(4,4'-Dimethoxytrityl)hexaethylene glycol; Hexaethylene Glycol Monodimethoxytrityl Ether; DMT-PEG6-OH; 2-[2-[2-[2-[2-[2-[(4,4'-Dimethoxytrityl)oxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol; 4,4'-Dimethoxytrityl hexaethylene glycol ether; Monomethoxytrityl-PEG6-alcohol (common misnomer); DMT-PEG6
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical applications. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) with detailed chromatographic data are available upon request. We adhere to a quality management system to ensure batch-to-batch consistency and reliability for your critical synthetic workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous oil or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 1.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.