Description

3-Chloro-5-Iodonitrobenzene is a halogenated nitroaromatic compound of significant interest in advanced organic synthesis. Its unique structure, featuring iodine, chlorine, and nitro substituents, makes it a versatile and valuable building block for constructing complex molecular architectures. This intermediate is primarily sought after by research institutions and chemical manufacturers in the pharmaceutical and agrochemical sectors. It serves as a key precursor for the development of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system and anti-infective applications.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and pesticides, leveraging its halogenated aromatic core.
• Material Science Research: Serves as a precursor for synthesizing specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing groups.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form biaryl and other complex structures.
• Nucleophilic Aromatic Substitution: The activated nitro and chloro groups facilitate substitution reactions for introducing diverse functional groups.
• Chemical Research & Development: Employed in academic and industrial R&D labs for method development and exploring new synthetic pathways.

Basic Information

Product Name	3-Chloro-5-Iodonitrobenzene
CAS No.	123158-76-9
Molecular Formula	C6H3ClINO2
Molecular Weight	299.45 g/mol
Synonyms	1-Chloro-3-iodo-5-nitrobenzene; 3-Chloro-5-iodonitrobenzene; 5-Chloro-1-iodo-3-nitrobenzene; 3-Chloro-5-iodo-1-nitrobenzene; 3-Iodo-5-chloronitrobenzene; Benzene, 1-chloro-3-iodo-5-nitro-; (3-Chloro-5-iodophenyl)nitro compound
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-Iodonitrobenzene is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to verify identity, potency, and impurity profiles. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.