Description

L-Homoserine Hydrochloride is a high-purity, non-proteinogenic amino acid derivative essential for advanced biochemical synthesis and research. This compound serves as a critical chiral building block and metabolic intermediate, offering significant value in the development of novel pharmaceuticals and fine chemicals. It is primarily utilized by research institutions, pharmaceutical manufacturers, and biotechnology companies engaged in peptide synthesis, metabolic pathway studies, and the production of specialized active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug molecules, antibiotics, and enzyme inhibitors.
• Biochemical Research: Used as a precursor in metabolic studies, particularly in the biosynthesis of threonine, methionine, and other amino acids.
• Peptide Synthesis: Serves as a protected amino acid derivative for the solid-phase and solution-phase synthesis of custom peptides and peptidomimetics.
• Microbiology & Fermentation: Employed as a defined component in microbial culture media for the selective growth of specific strains or for metabolic engineering.
• Reference Standard: Used as a high-purity analytical standard in HPLC, LC-MS, and NMR for quality control and method validation in laboratories.

Basic Information

Product Name	L-Homoserine Hydrochloride
CAS No.	123053-31-6
Molecular Formula	C4H9NO3·HCl
Molecular Weight	155.58 g/mol (Free base: 119.12 g/mol)
Synonyms	(S)-2-Amino-4-hydroxybutyric acid hydrochloride; L-2-Amino-4-hydroxybutanoic acid hydrochloride; (S)-Homoserine hydrochloride; L-Threonine isomer hydrochloride; Hse-OH·HCl; L-α-Amino-γ-hydroxybutyric acid hydrochloride; L-4-Hydroxynorvaline hydrochloride
EINECS	Contact for details

Quality Control

Our L-Homoserine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent absorption of atmospheric moisture, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]20/D	+14.0° to +16.0° (c=1 in H2O)
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Loss on Drying	≤1.0%
Residue on Ignition (Sulfated Ash)	≤0.1%
Heavy Metals (as Pb)	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.