Description

Xe 991 Dihydrochloride is a potent and selective inhibitor of the neuronal KCNQ (Kv7) potassium channels. This high-purity compound is essential for advanced neuroscience research, enabling the study of neuronal excitability, synaptic transmission, and related neurological pathways. It is a critical tool for pharmaceutical R&D teams and academic researchers focused on ion channel pharmacology, epilepsy, pain, and neurodegenerative disease models.

Application

• Neuroscience Research: A key pharmacological tool for studying the function and modulation of KCNQ (Kv7) potassium channels in neuronal circuits.
• Ion Channel Pharmacology: Used in in vitro and ex vivo assays to investigate channel kinetics, drug interactions, and mechanism of action studies.
• Disease Model Studies: Applied in research models for epilepsy, neuropathic pain, and other conditions linked to neuronal hyperexcitability.
• Pharmaceutical Development: Serves as a reference standard and lead compound in the discovery and validation of novel central nervous system (CNS) therapeutics.
• Academic & Institutional R&D: Supports fundamental research in university and institutional laboratories exploring neuronal signaling and channelopathies.
• Biochemical Assays: Utilized in high-throughput screening (HTS) and patch-clamp electrophysiology to identify and characterize new modulators.

Basic Information

Product Name	Xe 991 Dihydrochloride
CAS No.	122955-13-9
Molecular Formula	C₁₇H₁₉Cl₂N₃O
Molecular Weight	352.26 g/mol
Synonyms	10,10-Bis(4-pyridinylmethyl)-9(10H)-anthracenone dihydrochloride; XE-991; XE 991; XE991; N,N-Bis(4-pyridinylmethyl)anthracen-9(10H)-one dihydrochloride; KCNQ Channel Blocker XE-991; Kv7 Channel Inhibitor XE-991
EINECS	Contact for details

Quality Control

Every batch of Xe 991 Dihydrochloride is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure high purity and batch-to-batch consistency suitable for sensitive research applications. A detailed Certificate of Analysis (COA) providing purity, identity confirmation (HPLC, NMR), and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Solubility	Soluble in DMSO, Methanol; slightly soluble in Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.