Description

Fucose, L-, [6-3H] CAS NO 122760-10-5 is a high-specific-activity tritium-labeled derivative of the essential monosaccharide L-fucose. This radiolabeled compound is a critical tool for tracing and quantifying fucose metabolism, glycoconjugate biosynthesis, and cellular uptake pathways in biological research. It is indispensable for scientists in pharmaceutical R&D, biochemistry, and glycobiology who require precise, sensitive tracers for in vitro and in vivo studies.

Application

• Metabolic Pathway Tracing: Used to study the incorporation of fucose into glycoproteins, glycolipids, and other glycoconjugates within living cells and tissues.
• Glycobiology Research: Essential for investigating fucosylation processes, which are critical in cell signaling, immune response, and cancer metastasis.
• Pharmacokinetic Studies: Enables the tracking of drug candidates or biologics that are fucosylated or target fucose-related pathways.
• Enzyme Assay Development: Serves as a substrate for assays measuring the activity of fucosyltransferases and other related enzymes.
• Autoradiography & Imaging: Provides a detectable signal for imaging the spatial distribution of fucose in tissue sections or biofilms.
• Quality Control for Biologics: Can be used in R&D to monitor and optimize the fucosylation patterns of therapeutic antibodies, which impacts their efficacy.

Basic Information

Product Name	Fucose, L-, [6-3H]
CAS No.	122760-10-5
Molecular Formula	C6H12O5 (³H labeled)
Molecular Weight	~164.16 g/mol (varies with specific activity)
Synonyms	6-³H-L-Fucose; L-[6-³H]Fucose; Tritiated L-Fucose; (6R)-6-³H-6-Deoxy-L-galactose; 6-Deoxy-L-[6-³H]galactose; L-Galactomethylose-6-³H; Fucose-6-³H
EINECS	Contact for details

Quality Control

Every batch of L-[6-³H]Fucose is manufactured and analyzed under strict quality systems to ensure radiochemical purity, specific activity, and chemical stability. Comprehensive testing includes HPLC analysis for radiochemical purity and identity confirmation. A detailed Certificate of Analysis (COA), specifying batch-specific activity (Ci/mmol or GBq/mmol), purity, solvent, and concentration, is provided with each shipment to support regulatory compliance in research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at ≤ -20°C or as specified on the label. The product is light-sensitive (store away from light). Always handle radioactive materials according to local safety regulations and guidelines.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Identification (HPLC)	Conforms to reference standard
Radiochemical Purity (HPLC)	≥ 95%
Specific Activity	10-60 Ci/mmol (Contact for exact value)
Concentration	1 mCi/mL in aqueous ethanol (Contact for details)
Solvent	Ethanol:Water (9:1 v/v) or as specified

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.