Description

3-(1-Naphthyl)-D-Alanine Hydrochloride is a chiral, non-natural amino acid derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound serves as a critical building block for the development of novel peptide-based therapeutics and chiral catalysts. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, asymmetric synthesis, and the study of enzyme inhibitors. The high optical purity and defined stereochemistry of this D-isomer make it a valuable reagent for creating molecules with specific biological activities.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for peptide-based drugs.
• Asymmetric Synthesis: Used as a building block or chiral auxiliary in the synthesis of complex organic molecules requiring high enantiomeric purity.
• Biochemical Research: Employed in the study of enzyme-substrate interactions, receptor binding assays, and the design of enzyme inhibitors.
• Peptide Chemistry: Incorporated into custom peptides for structure-activity relationship (SAR) studies and the development of diagnostic tools or therapeutic peptides.
• Material Science: Potential use in the synthesis of specialty polymers and advanced materials where chiral centers impart specific physical properties.

Basic Information

Product Name	3-(1-Naphthyl)-D-Alanine Hydrochloride
CAS No.	122745-09-9
Molecular Formula	C₁₃H₁₃NO₂·HCl
Molecular Weight	251.71 g/mol (Free base: 215.25 g/mol)
Synonyms	D-3-(1-Naphthyl)alanine hydrochloride; (R)-2-Amino-3-(naphthalen-1-yl)propanoic acid hydrochloride; 1-Naphthyl-D-alanine HCl; D-1-Nal-OH·HCl; (R)-3-(1-Naphthyl)alanine hydrochloride; D-α-(1-Naphthyl)alanine hydrochloride; 3-(1-Naphthalenyl)-D-alanine hydrochloride
EINECS	Contact for details

Quality Control

Our 3-(1-Naphthyl)-D-Alanine Hydrochloride is manufactured under strict quality control protocols to ensure high chemical and chiral purity, meeting the exacting standards required for research and development. Each batch is analyzed using advanced techniques including HPLC, chiral analysis, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee (D-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.