Description

Magnesium Lithospermate B is a bioactive magnesium salt of lithospermic acid B, a polyphenolic compound isolated from the traditional medicinal herb *Salvia miltiorrhiza* (Danshen). It is valued for its potent antioxidant, anti-inflammatory, and cardiovascular-protective properties, making it a high-priority active pharmaceutical ingredient (API) for research and development in nutraceuticals and botanical therapeutics. Researchers and contract development and manufacturing organizations (CDMOs) in the pharmaceutical, functional food, and natural health product sectors rely on high-purity Magnesium Lithospermate B CAS NO 122021-74-3 for preclinical studies, formulation development, and clinical trial material synthesis.

Application

• Preclinical research on oxidative stress-related disorders (e.g., ischemia-reperfusion injury, diabetic complications)
• Development of cardioprotective nutraceutical formulations targeting endothelial function and microcirculation
• Standard reference material for HPLC and LC-MS quantification of lithospermic acid derivatives in herbal extracts
• Active ingredient in standardized botanical drug candidates under regulatory review (e.g., FDA Botanical Drug Pathway, EMA Herbal Medicinal Products)
• Stability-indicating assay component for quality control of Danshen-based phytomedicines
• Tool compound in mechanistic studies of Nrf2/ARE pathway activation and NF-κB inhibition

Basic Information

Product Name	Magnesium Lithospermate B
CAS No.	122021-74-3
Molecular Formula	C36H28MgO16
Molecular Weight	756.92 g/mol
Synonyms	Lithospermic acid B magnesium salt; Magnesium lithospermate; Magnesium bis(lithospermate B); Magnesium 3,3',4,4'-tetrahydroxy-5,5'-dicarboxy-2,2'-biphenyl-1,1'-diolate; Danshen-derived magnesium polyphenolate; ML-B; Magnesium lithospermate B (non-stoichiometric); Magnesium lithospermic acid B complex
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches are tested per ICH Q5, Q6A, and Q7 guidelines for biological source-derived actives, including identity confirmation (HPLC retention time match + UV spectral overlay), assay (HPLC-UV), residual solvents (GC), heavy metals (ICP-MS), microbial limits (USP & Ph. Eur. <61>), and absence of specified impurities (e.g., lithospermic acid A, rosmarinic acid, danshensu). Complies with ISO 9001:2015 and cGMP principles for botanical API manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C in a dry, well-ventilated area. Due to its hygroscopic nature, minimize exposure to ambient humidity; use desiccant during storage and handling. Avoid repeated opening of container.

Specification

Item	Specification
Appearance	Off-white to light brown amorphous powder
Odor	Characteristic mild herbal odor
Solubility	Soluble in DMSO, methanol, and aqueous alkaline solutions; sparingly soluble in water; insoluble in hexane
Identification (HPLC)	Retention time matches reference standard; UV spectrum (280 nm & 330 nm) consistent
Assay (HPLC-UV)	≥ 95.0% (on anhydrous basis)
Loss on Drying	≤ 5.0%
Residue on Ignition	≤ 3.0%
Heavy Metals (as Pb)	≤ 10 ppm
Microbial Limits	Total aerobic count ≤ 1000 CFU/g; Yeast & mold ≤ 100 CFU/g; Absence of E. coli, Salmonella, and S. aureus

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.