Description

1-Ethyl-6-Fluoro-7-Morpholin-4-Yl-4-Oxo-1,4-Dihydro-[1,8]Naphthyridine-3-Carboxylic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound matters as a critical building block in the synthesis of novel quinolone and naphthyridine-based active pharmaceutical ingredients (APIs), where its specific substitution pattern is essential for biological activity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries working on antibacterial agents and other therapeutic candidates.

Application

• Key Intermediate for Antibacterial APIs: Serves as a crucial precursor in the synthesis of next-generation fluoroquinolone and naphthyridone antibiotics, targeting DNA gyrase and topoisomerase IV.
• Pharmaceutical Research & Development: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and the development of new antibacterial entities.
• Process Chemistry & Scale-Up: Employed in the optimization and commercial-scale manufacturing routes for target drug molecules.
• Reference Standard: Utilized as an analytical standard for quality control and regulatory submissions in API production.
• Custom Synthesis Building Block: Provides a versatile scaffold for the custom synthesis of specialized chemical libraries and novel heterocyclic compounds for biological screening.

Basic Information

Item	Details
Product Name	1-Ethyl-6-Fluoro-7-Morpholin-4-Yl-4-Oxo-1,4-Dihydro-[1,8]Naphthyridine-3-Carboxylic Acid Ethyl Ester
CAS No.	121998-11-6
Molecular Formula	C₁₇H₂₀FN₃O₄
Molecular Weight	349.36 g/mol
Synonyms	Ethyl 1-Ethyl-6-fluoro-7-(morpholin-4-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate; 1-Ethyl-6-fluoro-7-morpholino-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid ethyl ester; 7-Morpholino-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester; 121998-11-6; 1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-1-ethyl-6-fluoro-7-(4-morpholinyl)-4-oxo-, ethyl ester; ENFQ Intermediate
EINECS	Contact for details

Quality Control

Our 1-Ethyl-6-Fluoro-7-Morpholin-4-Yl-4-Oxo-1,4-Dihydro-[1,8]Naphthyridine-3-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.