Description

6-Hydroxy-Dl-Norleucine Methyl Ester Hydrochloride is a protected amino acid derivative, a key chiral building block in advanced organic synthesis. Its primary value lies in providing a versatile intermediate for the construction of complex peptides and peptidomimetics, where the hydroxyl and ester functionalities offer orthogonal protection strategies. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly in the development of novel therapeutic agents and biochemical tools.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of peptide-based drugs, enzyme inhibitors, and other bioactive molecules.
• Biochemical Research: Used in the study of amino acid metabolism, enzyme mechanisms, and as a precursor for labeled compounds in tracer studies.
• Peptide Synthesis: Serves as a protected amino acid building block in solid-phase and solution-phase peptide synthesis (SPPS).
• Prodrug Development: The ester moiety can be utilized in prodrug strategies to enhance the bioavailability or targeting of active pharmaceutical ingredients (APIs).
• Chemical Biology: Employed in the synthesis of molecular probes and tools for investigating protein-protein interactions and cellular pathways.
• Agrochemical Research: Potential intermediate in the development of novel, biologically active compounds for crop protection.

Basic Information

Product Name	6-Hydroxy-Dl-Norleucine Methyl Ester Hydrochloride
CAS No.	121895-18-9
Molecular Formula	C8H18ClNO3
Molecular Weight	211.69 g/mol
Synonyms	DL-6-Hydroxynorleucine Methyl Ester Hydrochloride; Methyl 2-Amino-6-hydroxyhexanoate Hydrochloride; 2-Amino-6-hydroxycaproic Acid Methyl Ester Hydrochloride; Norleucine, 6-hydroxy-, methyl ester, hydrochloride, DL-; Methyl DL-6-Hydroxynorleucinate Hydrochloride; 6-Hydroxy-DL-norleucine methyl ester HCl
EINECS	Contact for details

Quality Control

Our 6-Hydroxy-Dl-Norleucine Methyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Purity (Chiral HPLC)	DL-mixture
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.