Description

(E)-3-[2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolyl]-Acrolein is a high-purity, advanced pharmaceutical intermediate characterized by its specific quinoline-based molecular architecture. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) targeting specific therapeutic pathways. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel small-molecule drugs, particularly within oncology and antiviral research domains.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of investigational new drugs (INDs) and novel chemical entities (NCEs).
• Organic Synthesis Research: Used in academic and industrial R&D for constructing complex heterocyclic frameworks and studying structure-activity relationships (SAR).
• Preclinical Drug Development: Serves as a critical precursor in the production of candidate compounds for pharmacological screening and toxicology studies.
• Chemical Reference Standard: Employed as a high-purity standard for analytical method development, validation, and quality control in API manufacturing.

Basic Information

Product Name	(E)-3-[2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolyl]-Acrolein
CAS No.	121660-63-7
Molecular Formula	C21H16FNO
Molecular Weight	317.36 g/mol
Synonyms	(E)-3-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)acrylaldehyde; 2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolineacrolein; 3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-2-propenal; (E)-3-(2-Cyclopropyl-4-(p-fluorophenyl)-3-quinolyl)acrolein; Acrolein, 3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-, (E)-
EINECS	Contact for details

Quality Control

Our production of (E)-3-[2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolyl]-Acrolein adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.