Description

4-(2-Cbz-Aminoethyl)Benzoic Acid is a key pharmaceutical intermediate featuring a benzoic acid core linked to a carboxybenzyl (Cbz)-protected aminoethyl group. This compound matters for its role as a versatile building block in the synthesis of complex molecules, particularly in peptide chemistry and drug discovery. It is primarily needed by research institutions and manufacturers in the pharmaceutical and biotechnology industries for developing new active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis, where the Cbz group serves as a temporary protecting group for amines.
• Protease Inhibitor Research: Serves as a core structural component in the development of enzyme inhibitors targeting various proteases.
• Linker Molecule in Bioconjugation: The carboxylic acid functionality allows for covalent attachment to other molecules, proteins, or solid supports.
• Chemical Biology Probes: Utilized in the creation of probes for studying biological pathways and protein functions.
• Academic & Industrial R&D: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.

Basic Information

Product Name	4-(2-Cbz-Aminoethyl)Benzoic Acid
CAS No.	121632-81-3
Molecular Formula	C₁₇H₁₇NO₄
Molecular Weight	299.32 g/mol
Synonyms	4-[2-[(Benzyloxy)carbonylamino]ethyl]benzoic Acid; 4-(2-((Benzyloxycarbonyl)amino)ethyl)benzoic Acid; N-Cbz-2-(4-Carboxyphenyl)ethylamine; 2-(4-Carboxyphenyl)ethylcarbamic Acid Benzyl Ester; 4-(2-(Benzyloxycarbonylamino)ethyl)benzoic Acid; Benzoic acid, 4-[2-[[(phenylmethoxy)carbonyl]amino]ethyl]-; Z-4-Aminomethylbenzoic Acid (common abbreviation context); Cbz-Tyr(Me)-OH related intermediate
EINECS	Contact for details

Quality Control

Our 4-(2-Cbz-Aminoethyl)Benzoic Acid is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.