Description

2-Chloro-3,5-Difluoro-4-(Trifluoromethyl)Phenyl Hydrazine is a high-value, multi-functional aromatic hydrazine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring chloro, difluoro, and trifluoromethyl substituents, makes it an essential intermediate for creating complex molecules with tailored properties. This compound is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly in the development of fluorinated small molecules for oncology, CNS, and anti-infective therapies.
• Agrochemical Synthesis: Used to construct advanced herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity, metabolic stability, and lipophilicity.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Dye & Pigment Industry: Intermediate for manufacturing high-performance, light-fast fluorinated dyes and pigments.
• Cross-Coupling Reactions: Valuable reagent in palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination) to introduce nitrogen-containing functional groups.
• Chemical Research & Development: A versatile scaffold for medicinal chemistry and process chemistry research to explore new chemical spaces.

Basic Information

Product Name	2-Chloro-3,5-Difluoro-4-(Trifluoromethyl)Phenyl Hydrazine
CAS No.	121435-36-7
Molecular Formula	C7H4ClF5N2
Molecular Weight	246.57 g/mol
Synonyms	2-Chloro-3,5-difluoro-4-(trifluoromethyl)phenylhydrazine; (2-Chloro-3,5-difluoro-4-(trifluoromethyl)phenyl)hydrazine; 1-(2-Chloro-3,5-difluoro-4-(trifluoromethyl)phenyl)hydrazine; Hydrazine, [2-chloro-3,5-difluoro-4-(trifluoromethyl)phenyl]-; 121435-36-7; 2-Chloro-3,5-difluoro-4-trifluoromethylphenylhydrazine; 4-Hydrazinyl-2-chloro-1,3-difluoro-5-(trifluoromethyl)benzene
EINECS	Contact for details

Quality Control

Our 2-Chloro-3,5-Difluoro-4-(Trifluoromethyl)Phenyl Hydrazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP and ISO 9001 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to light and propensity for oxidation, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.