Description

(1R,2S,4R,6R)-2,4-Bis(tert-Butyldimethylsilyloxy)-1-Methyl-Cyclohexane 1,2-Epoxide is a high-purity, chiral epoxide intermediate featuring dual tert-butyldimethylsilyl (TBDMS) protecting groups. This compound is critical for its role in stereoselective synthesis, enabling the controlled construction of complex molecular architectures. It is primarily needed by research institutions and pharmaceutical manufacturers developing advanced active pharmaceutical ingredients (APIs) and fine chemicals where precise stereochemistry is paramount.

Application

• Chiral Intermediate for Pharmaceutical Synthesis: A key building block in the multi-step synthesis of complex drug molecules, particularly in oncology and antiviral research.
• Asymmetric Catalysis Research: Used as a substrate or ligand precursor in the development of new asymmetric catalytic reactions.
• Natural Product Synthesis: Serves as a critical intermediate in the total synthesis of complex natural products with multiple stereocenters.
• Advanced Material Precursor: Can be utilized in the synthesis of specialized polymers or liquid crystals with specific optical properties.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale for new chemical entities.
• Academic & Industrial R&D: A valuable reagent for exploring new synthetic methodologies in organic and medicinal chemistry.

Basic Information

Product Name	(1R,2S,4R,6R)-2,4-Bis(tert-Butyldimethylsilyloxy)-1-Methyl-Cyclohexane 1,2-Epoxide
CAS No.	121289-20-1
Molecular Formula	C21H44O3Si2
Molecular Weight	400.75 g/mol
Synonyms	1,2-Epoxy-1-methyl-2,4-bis[(1,1-dimethylethyl)dimethylsilyl]oxy]cyclohexane; (1R,2S,4R,6R)-1-Methyl-2,4-bis[(tert-butyldimethylsilyl)oxy]cyclohexane 1,2-epoxide; TBDMS-protected cyclohexane epoxide; (1R,2S,4R,6R)-2,4-Bis-O-(tert-butyldimethylsilyl)-1-methyl-cyclohexane-1,2-epoxide; Chiral TBDMS epoxide intermediate; 1-Methyl-2,4-bis-O-TBDMS-cyclohexane oxide
EINECS	Contact for details

Quality Control

Our (1R,2S,4R,6R)-2,4-Bis(tert-Butyldimethylsilyloxy)-1-Methyl-Cyclohexane 1,2-Epoxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high enantiomeric and chemical purity suitable for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.