Description

trans-6-Methyl-4-Ethylamino-5,6-Dihydro-4H-Thieno[2,3-B]Thiopyran-2-Sulfonamide-7,7-Dioxide is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused heterocyclic structure. This compound matters as a critical building block in the synthesis of novel therapeutic agents, offering researchers a reliable and well-defined starting material for complex molecular construction. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries, particularly those focused on developing new chemical entities for metabolic and ophthalmic applications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel carbonic anhydrase inhibitors for therapeutic development.
• Ophthalmic Drug Research: Used in the research and development of potential treatments for glaucoma and other intraocular pressure disorders.
• Metabolic Disorder Research: Serves as a core scaffold for compounds being investigated for conditions like epilepsy and altitude sickness.
• Chemical Biology Probe Development: Utilized to create selective inhibitors for studying carbonic anhydrase isoforms and their physiological roles.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Academic & Institutional Research: Provides a specialized heterocyclic compound for medicinal chemistry programs and structure-activity relationship (SAR) studies.

Basic Information

Product Name	trans-6-Methyl-4-Ethylamino-5,6-Dihydro-4H-Thieno[2,3-B]Thiopyran-2-Sulfonamide-7,7-Dioxide
CAS No.	120280-13-9
Molecular Formula	C11H16N2O4S3
Molecular Weight	336.45 g/mol
Synonyms	trans-6-Methyl-4-ethylamino-4,5-dihydro-2H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide; 4,5-Dihydro-6-methyl-4-(ethylamino)-2H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide; (4R,6R)-6-Methyl-4-(ethylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide; L-714,465; L 714465; L714465; A thienothiopyran sulfonamide derivative; Ethylamino-thienothiopyran sulfonamide dioxide
EINECS	Contact for details

Quality Control

Our trans-6-Methyl-4-Ethylamino-5,6-Dihydro-4H-Thieno[2,3-B]Thiopyran-2-Sulfonamide-7,7-Dioxide is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (trans-isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.