Description

5-Amino-1,3,4-Thiadiazole-2-Sulfonamide Hydrochloride Salt is a high-purity, specialized heterocyclic sulfonamide building block of significant importance in advanced organic synthesis. This compound is valued for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs), particularly those targeting carbonic anhydrase enzymes. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for creating novel therapeutic agents and high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of carbonic anhydrase inhibitors used in medications for glaucoma, epilepsy, and altitude sickness.
• Agrochemical Research: Serves as a core scaffold for developing new herbicides and fungicides with specific modes of action.
• Fine Chemical Synthesis: Used in constructing complex heterocyclic compounds for material science and specialty chemical applications.
• Biochemical Tool Compound: Employed in life science research as a standard or probe for studying enzyme kinetics and inhibition.
• API Development: Integral to the research and scale-up processes for new drug candidates in preclinical and clinical development stages.

Basic Information

Product Name	5-Amino-1,3,4-Thiadiazole-2-Sulfonamide Hydrochloride Salt
CAS No.	120208-98-2
Molecular Formula	C2H5ClN4O2S2
Molecular Weight	232.67 g/mol
Synonyms	5-Amino-1,3,4-thiadiazole-2-sulfonamide monohydrochloride; 2-Sulfamoyl-1,3,4-thiadiazol-5-amine hydrochloride; Acetazolamide Intermediate; 5-Amino-1,3,4-thiadiazole-2-sulphonamide hydrochloride; AAZ Intermediate; 1,3,4-Thiadiazol-2-amine, 5-sulfonyl-, hydrochloride; TZSA hydrochloride
EINECS	Contact for details

Quality Control

Our 5-Amino-1,3,4-Thiadiazole-2-Sulfonamide Hydrochloride Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting standards for research and production use. Certificates of Analysis (COA) documenting full specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.