Description

2,5-Difluoro-4-Nitrophenol is a high-purity fluorinated nitrophenol derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both electron-withdrawing nitro and fluoro substituents, makes it an invaluable intermediate for creating complex molecules with tailored properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), especially in fluorinated drug candidates targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, pesticides, and fungicides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving performance characteristics.
• Dye & Pigment Manufacturing: Acts as an intermediate for synthesizing specialized dyes and pigments with specific color fastness and solubility properties.
• Polymer Modification: Employed to introduce fluorophenol groups into polymer chains, altering surface properties, chemical resistance, and thermal stability.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing complex biaryl systems in medicinal chemistry.

Basic Information

Product Name	2,5-Difluoro-4-Nitrophenol
CAS No.	120103-18-6
Molecular Formula	C6H3F2NO3
Molecular Weight	175.09 g/mol
Synonyms	4-Nitro-2,5-difluorophenol; 2,5-Difluoro-4-nitro-1-hydroxybenzene; 1-Hydroxy-2,5-difluoro-4-nitrobenzene; Phenol, 2,5-difluoro-4-nitro-; 2,5-Difluoro-4-nitrophenol; 120103-18-6; 4-Nitro-2,5-difluorophenol
EINECS	Contact for details

Quality Control

Our 2,5-Difluoro-4-Nitrophenol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support custom synthesis and can tailor purity grades to meet specific research or cGMP requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be amber-colored or stored in a dark place.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.