Description

6-Ethynyl-3,4-Dihydroquinolin-2(1H)-One is a high-purity, advanced pharmaceutical intermediate featuring a unique ethynyl-substituted quinolinone scaffold. This compound is of significant commercial importance for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex heterocyclic compounds for medicinal chemistry research.
• Drug Discovery Scaffold: Serves as a core structural element for developing new chemical entities targeting various therapeutic areas.
• Organic Synthesis Building Block: Used in palladium-catalyzed cross-coupling reactions (e.g., Sonogashira coupling) due to the reactive ethynyl group.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents and pesticides.
• Material Science: Investigated as a monomer or precursor for specialty polymers and advanced organic materials.

Basic Information

Product Name	6-Ethynyl-3,4-Dihydroquinolin-2(1H)-One
CAS No.	120067-46-1
Molecular Formula	C11H9NO
Molecular Weight	171.20 g/mol
Synonyms	6-Ethynyl-1,2,3,4-tetrahydroquinolin-2-one; 6-Ethynyl-3,4-dihydro-2(1H)-quinolinone; 2(1H)-Quinolinone, 6-ethynyl-3,4-dihydro-; 6-Ethynyl-1,2,3,4-tetrahydro-2-quinolone; 6-Ethynyl-2-oxo-1,2,3,4-tetrahydroquinoline
EINECS	Contact for details

Quality Control

Our 6-Ethynyl-3,4-Dihydroquinolin-2(1H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 15-25°C. This material is light-sensitive and easily oxidized; prolonged exposure to air or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.