Description

β-Hydroxy-β-Methyl-α-Phenyl-(1,1'-Biphenyl)-4-Propanoic Acid, (R',S')-(-)- is a high-purity, stereochemically defined chiral intermediate of significant importance in advanced organic synthesis. This compound matters for its role as a critical building block in the development of pharmaceutical active ingredients, enabling precise control over molecular architecture. It is primarily needed by research and development laboratories, process chemists, and manufacturers in the pharmaceutical and fine chemical industries for creating novel therapeutic agents and high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel drug candidates, particularly in therapeutic areas requiring complex, stereospecific molecules.
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric reactions to construct molecules with high enantiomeric purity.
• Fine Chemical Production: Used in the multi-step synthesis of advanced agrochemicals, specialty polymers, and performance materials.
• Academic & Industrial R&D: Serves as a valuable reference standard and starting material for method development and discovery chemistry in both academic and corporate settings.
• Process Chemistry & Scale-Up: Integral to route scouting and optimization studies for the efficient and cost-effective manufacturing of complex organic compounds.

Basic Information

Product Name	β-Hydroxy-β-Methyl-α-Phenyl-(1,1'-Biphenyl)-4-Propanoic Acid, (R',S')-(-)-
CAS No.	119725-44-9
Molecular Formula	C23H22O3
Molecular Weight	346.42 g/mol
Synonyms	(R',S')-(-)-β-Hydroxy-β-methyl-α-phenyl-[1,1'-biphenyl]-4-propanoic acid; (R,S)-Atorvastatin Lactone Intermediate; (3R,5S)-7-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid lactone derivative; Biphenylpropanoic acid derivative; Atorvastatin Lactone Diastereomer; [1,1'-Biphenyl]-4-propanoic acid, β-hydroxy-β-methyl-α-phenyl-, (αR,βS)-rel-(-)-; Chiral Hydroxy Acid Intermediate.
EINECS	Contact for details

Quality Control

Our β-Hydroxy-β-Methyl-α-Phenyl-(1,1'-Biphenyl)-4-Propanoic Acid, (R',S')-(-)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC, NMR, and mass spectrometry, to ensure identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; therefore, containers should be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de (Diastereomeric Excess)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.