Description

β-Hydroxy-α-Phenyl-(1,1'-Biphenyl)-4-Propanoic Acid, (R',R')-(-)- CAS NO 119725-34-7 is a high-purity, chiral organic compound belonging to the class of biphenyl-substituted propanoic acids. This material is a critical chiral intermediate and building block for the synthesis of advanced pharmaceutical active ingredients and fine chemicals. It is primarily utilized by research and development laboratories, process chemists, and manufacturers in the pharmaceutical and agrochemical industries who require enantiomerically pure intermediates for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of non-steroidal anti-inflammatory drugs (NSAIDs) and other bioactive molecules.
• Asymmetric Synthesis: Used as a building block or resolving agent in catalytic asymmetric reactions to introduce stereochemical complexity.
• Agrochemical Research: Serves as a precursor in the development of novel, enantiomerically pure herbicides and pesticides.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands for transition metal catalysis.
• Academic and Industrial R&D: A valuable compound for methodological studies in organic synthesis and process chemistry.
• Fine Chemical Production: Used in the manufacture of specialty chemicals requiring specific stereochemistry.

Basic Information

Product Name	β-Hydroxy-α-Phenyl-(1,1'-Biphenyl)-4-Propanoic Acid, (R',R')-(-)-
CAS No.	119725-34-7
Molecular Formula	C21H18O3
Molecular Weight	318.37 g/mol
Synonyms	(R,R)-(-)-2-Hydroxy-2-phenyl-3-(4-biphenylyl)propionic Acid; (R,R)-2-Hydroxy-2-phenyl-3-(biphenyl-4-yl)propanoic Acid; (R,R)-2-Hydroxy-3-(4-phenylphenyl)-2-phenylpropanoic Acid; (R,R)-α-Phenyl-β-hydroxy-4-biphenylpropanoic Acid; (-)-[R-(R*,R*)]-α-Phenyl-β-hydroxy-4-biphenylpropanoic Acid; (R,R)-HPPA; Biphenylpropanoic Acid Derivative
EINECS	Contact for details

Quality Control

Our production of β-Hydroxy-α-Phenyl-(1,1'-Biphenyl)-4-Propanoic Acid, (R',R')-(-)- adheres to stringent quality management protocols. Each batch is subjected to comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure high enantiomeric excess (e.e.) and chemical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. Our quality systems support compliance with cGMP and ISO standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light exposure to maintain stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.