Description

2,6-Difluorophenylhydrazine is a specialized aromatic hydrazine derivative that serves as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms on the phenyl ring, which significantly influences the electronic and steric properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and complex heterocyclic compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting the central nervous system and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the difluorophenyl moiety enhances biological activity and environmental stability.
• Material Science Research: Building block for creating novel polymers, liquid crystals, and organic electronic materials with tailored properties.
• Dye and Pigment Manufacturing: Intermediate in the synthesis of specialized dyes and colorants requiring high thermal and chemical stability.
• Cross-coupling Reactions: Valuable reagent in palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination) to construct complex nitrogen-containing architectures.
• Heterocyclic Chemistry: Fundamental starting material for constructing pyrazole, indazole, and other nitrogen-based heterocycles prevalent in medicinal chemistry.

Basic Information

Product Name	2,6-Difluorophenylhydrazine
CAS No.	119452-66-3
Molecular Formula	C6H6F2N2
Molecular Weight	144.12 g/mol
Synonyms	(2,6-Difluorophenyl)hydrazine; 1-(2,6-Difluorophenyl)hydrazine; 2,6-Difluorophenyl-hydrazine; Hydrazine, (2,6-difluorophenyl)-; 2,6-DFPH
EINECS	Contact for details

Quality Control

Our 2,6-Difluorophenylhydrazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity determination, to meet the stringent requirements of our global clientele in fine chemical synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, open flames, and incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.