Description

Cytidine, n-Benzoyl-2'-Deoxy-2'-Oxo-3',5'-o-[1,1,3,3-Tetrakis(1-Methylethyl)-1,3-Disiloxanediyl]- is a sophisticated, protected nucleoside derivative of significant value in advanced organic synthesis. This compound is a critical high-purity building block for the controlled construction of oligonucleotides and modified nucleic acids. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel therapeutics, including antisense oligonucleotides and other nucleic acid-based drugs. CAS No. 119411-03-9.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of DNA and RNA strands, particularly where specific base modifications are required.
• Antisense Drug Development: Used in the research and production of antisense oligonucleotides (ASOs) designed to target and modulate gene expression for therapeutic purposes.
• siRNA and miRNA Synthesis: Serves as a protected monomer in the manufacture of small interfering RNA (siRNA) and microRNA (miRNA) for gene silencing applications.
• Pharmaceutical Intermediates: Acts as a crucial intermediate in the multi-step synthesis of complex nucleoside-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed in academic and industrial research to study nucleic acid structure, function, and to create probes or primers with specific properties.
• Diagnostic Reagent Manufacturing: Utilized in the production of labeled nucleotides and other components for diagnostic kits and assays.

Basic Information

Product Name	Cytidine, n-Benzoyl-2'-Deoxy-2'-Oxo-3',5'-o-[1,1,3,3-Tetrakis(1-Methylethyl)-1,3-Disiloxanediyl]-
CAS No.	119411-03-9
Molecular Formula	C31H48N3O7Si2
Molecular Weight	630.90 g/mol
Synonyms	5'-O-(1,1,3,3-Tetraisopropyldisiloxane-1,3-diyl)-N-benzoyl-2'-deoxy-2'-oxocytidine; 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-N-benzoyl-2'-deoxy-2'-oxocytidine; N-Benzoyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxy-2'-oxocytidine; TIPDS-protected N-benzoyl-2'-deoxy-2'-oxocytidine; 2'-Keto-N-benzoylcytidine 3',5'-TIPDS ether; N4-Benzoyl-2'-deoxy-2'-oxocytidine 3',5'-bis(TIPDS) derivative
EINECS	Contact for details

Quality Control

This high-value synthetic intermediate is produced under strict quality-controlled conditions to ensure batch-to-batch consistency and purity suitable for sensitive pharmaceutical applications. Our quality assurance includes comprehensive analytical characterization using HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We adhere to cGMP guidelines for the manufacture of advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere (argon or nitrogen) in a desiccator.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.