Description

Cholanthrene-9,10-Diol-7,8-Epoxide is a high-purity, reactive polycyclic aromatic hydrocarbon (PAH) derivative. This compound is of significant interest in advanced organic synthesis and biochemical research due to its role as a model electrophilic metabolite and DNA adduct-forming agent. It is primarily utilized by research institutions and pharmaceutical development laboratories for mechanistic studies in carcinogenesis, toxicology, and metabolic pathway analysis.

Application

• Biochemical Research: Used as a critical reference standard and reagent in studies of metabolic activation pathways of polycyclic aromatic hydrocarbons (PAHs).
• Toxicology & Carcinogenesis Studies: Serves as a model ultimate carcinogen for investigating DNA adduct formation, mutagenicity, and cellular repair mechanisms.
• Pharmaceutical Development: Employed in the synthesis and testing of novel chemopreventive agents or inhibitors targeting specific cytochrome P450 enzymes.
• Analytical Chemistry: Acts as a high-purity calibration standard for advanced analytical techniques like HPLC-MS and GC-MS in environmental and biological monitoring.
• Academic Research: Fundamental tool in organic chemistry and medicinal chemistry programs for studying epoxide reactivity and stereoselective synthesis.

Basic Information

Product Name	Cholanthrene-9,10-Diol-7,8-Epoxide
CAS No.	119181-09-8
Molecular Formula	C20H12O3
Molecular Weight	300.31 g/mol
Synonyms	7,8-Epoxy-9,10-dihydroxy-7,8,9,10-tetrahydrocholanthrene; 3,4-Epoxy-1,2-dihydroxy-1,2,3,4-tetrahydrocholanthrene; Cholanthrene 9,10-diol 7,8-epoxide; (±)-anti-Cholanthrene-9,10-diol-7,8-epoxide; anti-Cholanthrene-9,10-dihydrodiol-7,8-epoxide; 7,8α-Epoxy-9β,10β-dihydroxy-7,8,9,10-tetrahydrocholanthrene; Cholanthrene diol epoxide
EINECS	Contact for details

Quality Control

Our Cholanthrene-9,10-Diol-7,8-Epoxide is manufactured under strict quality protocols to ensure batch-to-batch consistency and high chemical purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to ISO 9001 quality management principles, and our analytical methods are validated to ensure reliable and accurate results for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials. Allow the product to reach room temperature in the sealed container before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light tan solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in common organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.