Description

(S,S)-2,6-Bis(4-Isopropyl-2-Oxazolin-2-Yl)Pyridine is a high-purity, chiral ligand belonging to the bis(oxazoline) class. This compound is of significant commercial importance due to its exceptional ability to induce stereoselectivity in transition metal-catalyzed reactions, enabling the production of enantiomerically pure intermediates. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for asymmetric synthesis, including Diels-Alder, cyclopropanation, and aldol reactions.

Application

• Asymmetric Catalysis: As a chiral ligand for copper, iron, nickel, and palladium complexes in enantioselective transformations.
• Pharmaceutical Intermediates: Synthesis of chiral active pharmaceutical ingredients (APIs) requiring high enantiomeric excess.
• Agrochemical Synthesis: Production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Manufacturing: Key reagent in the preparation of specialty chemicals, flavors, and fragrances.
• Academic & Industrial R&D: A critical tool for developing new catalytic methodologies and exploring novel reaction pathways.
• Material Science: Potential use in the synthesis of chiral polymers and advanced functional materials.

Basic Information

Product Name	(S,S)-2,6-Bis(4-Isopropyl-2-Oxazolin-2-Yl)Pyridine
CAS No.	118949-61-4
Molecular Formula	C21H29N3O2
Molecular Weight	355.48 g/mol
Synonyms	(S,S)-2,6-Bis[(4S)-4-isopropyl-4,5-dihydro-2-oxazolyl]pyridine; (S,S)-PyBOX-iPr; (S,S)-2,6-Bis(4-isopropyl-4,5-dihydrooxazol-2-yl)pyridine; (S,S)-2,6-Bis(4-isopropyl-2-oxazolinyl)pyridine; (S,S)-Bis(4-isopropyl-2-oxazolinyl)pyridine; (S,S)-iPr-PyBOX; (4S,4'S)-2,6-Bis(4-isopropyl-4,5-dihydrooxazol-2-yl)pyridine
EINECS	Contact for details

Quality Control

Our (S,S)-2,6-Bis(4-Isopropyl-2-Oxazolin-2-Yl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and chiral integrity, meeting the stringent requirements for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC/NMR), enantiomeric excess, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.