Description

5,8-Dideazapteroylornithine is a specialized folate analog and a key intermediate in the synthesis of novel antifolate compounds. This high-purity building block is critical for pharmaceutical research and development, particularly in the design of targeted chemotherapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology drug discovery and the development of enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel antifolate drugs and enzyme inhibitors.
• Oncology Research: Used in the development and screening of potential chemotherapeutic agents targeting folate metabolism pathways.
• Biochemical Research: Serves as a tool compound for studying enzyme kinetics and inhibition mechanisms of folate-dependent enzymes.
• Reference Standard: Employed as an analytical standard in quality control and method development for pharmaceutical manufacturing.
• Academic Research: Utilized in university and institutional labs for fundamental studies in medicinal chemistry and biochemistry.

Basic Information

Item	Detail
Product Name	5,8-Dideazapteroylornithine
CAS No.	118675-83-5
Molecular Formula	C20H24N6O5
Molecular Weight	428.44 g/mol
Synonyms	5,8-Dideazapteroyl-L-ornithine; DDAPO; N-[4-[[(2-Amino-4-oxo-1,4-dihydro-6-pteridinyl)methyl]amino]benzoyl]-L-ornithine; L-Ornithine, N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-; 5,8-Dideazapteroic acid ornithine derivative; Antifolate intermediate; Folate analog intermediate
EINECS	Contact for details

Quality Control

Our 5,8-Dideazapteroylornithine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to yellow powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.