Description

2-(4-Chlorophenyl)Malonic Acid is a versatile bifunctional organic building block featuring both a carboxylic acid and a malonate moiety on a chlorinated aromatic core. This compound is valued for its role as a key intermediate in the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and agrochemical industries for constructing active pharmaceutical ingredients (APIs) and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of non-steroidal anti-inflammatory drugs (NSAIDs), receptor antagonists, and other bioactive molecules.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators, leveraging the chlorophenyl group for biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating chelating ligands and organocatalysts used in asymmetric synthesis.
• Polymer Chemistry: Acts as a monomer or cross-linking agent for producing specialty polymers with tailored thermal and mechanical properties.
• Material Science Research: Employed in the development of organic semiconductors, metal-organic frameworks (MOFs), and other advanced functional materials.
• Chemical Biology Probes: Utilized to synthesize molecular probes and tags for studying biological processes and enzyme inhibition.

Basic Information

Item	Details
Product Name	2-(4-Chlorophenyl)Malonic Acid
CAS No.	118459-48-6
Molecular Formula	C9H7ClO4
Molecular Weight	214.60 g/mol
Synonyms	4-Chlorophenylmalonic Acid; (4-Chlorophenyl)propanedioic Acid; 2-(p-Chlorophenyl)malonic Acid; 4-Chloro-alpha,alpha'-dicarboxytoluene; Propanedioic acid, 2-(4-chlorophenyl)-; p-Chlorophenylmalonic Acid
EINECS	Contact for details

Quality Control

Our 2-(4-Chlorophenyl)Malonic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed to prevent absorption of atmospheric moisture, which can affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	158 - 162 °C
Loss on Drying	≤ 1.0%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.