Description

Nodularin CAS NO 118399-22-7 is a potent cyclic pentapeptide hepatotoxin produced by certain species of cyanobacteria, primarily *Nodularia spumigena*. This compound is of significant interest for its role as a reference standard in environmental monitoring and toxicological research, enabling the detection and quantification of harmful algal blooms in water bodies. It is essential for laboratories and institutions focused on water safety, marine biology, and the development of diagnostic assays for cyanobacterial toxins.

Application

• Environmental Monitoring: Used as a certified reference material for the analysis of cyanobacterial toxins in freshwater and marine samples.
• Toxicological Research: Serves as a key standard in studies investigating the mechanisms of hepatotoxicity, tumor promotion, and protein phosphatase inhibition.
• Diagnostic Development: Critical for the calibration and validation of analytical methods such as HPLC, LC-MS/MS, and ELISA kits for nodularin detection.
• Water Quality Assurance: Employed by regulatory bodies and testing laboratories to establish safety thresholds and compliance standards for drinking and recreational water.
• Biochemical Studies: Utilized in research exploring enzyme inhibition, particularly against protein phosphatases PP1 and PP2A.
• Food and Feed Safety: Applied in the analysis of seafood and agricultural products for potential cyanotoxin contamination.

Basic Information

Item	Details
Product Name	Nodularin
CAS No.	118399-22-7
Molecular Formula	C41H60N8O10
Molecular Weight	824.98 g/mol
Synonyms	Nodularin-R; Nodularin variant; Cyanobacterial hepatotoxin; [ADMAdda5]microcystin-LR; Cyclo[(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoyl-D-erythro-β-methylaspartyl-(2Z)-2-(methylamino)-2-butenoyl-N-methyl-dehydroalanyl-D-alanine]
EINECS	Contact for details

Quality Control

Every batch of Nodularin is produced and analyzed under strict quality protocols to ensure the highest standards of identity, purity, and stability. Our analytical methods, including high-performance liquid chromatography (HPLC) and mass spectrometry (MS), are validated to provide precise quantification. A comprehensive Certificate of Analysis (COA) detailing purity, identification, and impurity profiles is provided with each shipment to support your research and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to structure
Purity (HPLC)	≥ 95% (Area Percent)
Water Content (KF)	≤ 1.0 %
Solubility	Soluble in methanol, DMSO; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.