Description

n-Me-His-Ome Hcl CAS NO 118384-75-1 is a protected derivative of the amino acid histidine, specifically N-methyl-L-histidine methyl ester hydrochloride. This compound serves as a crucial building block (synthon) in advanced organic synthesis, particularly for the construction of complex peptides and peptidomimetics. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers engaged in drug discovery and development.

Application

• Peptide Synthesis: As a key intermediate for introducing modified histidine residues into peptide chains.
• Pharmaceutical Research: In the discovery and development of novel therapeutic agents, including enzyme inhibitors and receptor ligands.
• Bioconjugation: For creating labeled peptides or peptide-based probes for diagnostic and research applications.
• Chemical Biology: As a tool compound for studying protein-protein interactions and enzyme mechanisms.
• Fine Chemical Production: Serving as a precursor for the synthesis of more complex, high-value specialty chemicals.

Basic Information

Product Name	n-Me-His-Ome Hcl
CAS No.	118384-75-1
Molecular Formula	C9H16ClN3O2
Molecular Weight	233.70 g/mol
Synonyms	N-Methyl-L-histidine methyl ester hydrochloride; Methyl (2S)-3-(1-methyl-1H-imidazol-5-yl)-2-(methylamino)propanoate hydrochloride; L-Histidine, N-methyl-, methyl ester, hydrochloride; 1-Methyl-L-histidine methyl ester hydrochloride; N(τ)-Methyl-L-histidine methyl ester hydrochloride; Methyl N-methyl-L-histidinate hydrochloride
EINECS	Contact for details

Quality Control

Our n-Me-His-Ome Hcl is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, IR), to ensure it meets exacting standards for research and synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.