Description

1,2,3,4-Tetrahydroquinoline-5-Carboxylic Acid Ethyl Ester is a versatile heterocyclic building block and key synthetic intermediate. This compound matters for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and advanced organic materials. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for lead optimization and scalable synthesis.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of quinoline-based drug candidates, including potential kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that leverage the quinoline scaffold for bioactivity.
• Organic Light-Emitting Diodes (OLEDs): Serves as a building block for electron-transport or emissive layer materials in advanced display technologies.
• Ligand and Catalyst Development: Employed in the preparation of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Dye and Pigment Research: Acts as a starting material for the development of specialized quinoline-derived colorants and fluorescent markers.
• Academic and R&D Laboratories: A valuable reagent for methodological studies in organic chemistry, including novel cyclization and functionalization reactions.

Basic Information

Item	Details
Product Name	1,2,3,4-Tetrahydroquinoline-5-Carboxylic Acid Ethyl Ester
CAS No.	118128-78-2
Molecular Formula	C₁₂H₁₅NO₂
Molecular Weight	205.25 g/mol
Synonyms	Ethyl 1,2,3,4-tetrahydro-5-quinolinecarboxylate; Ethyl 1,2,3,4-tetrahydroquinoline-5-carboxylate; 5-Carbethoxy-1,2,3,4-tetrahydroquinoline; 1,2,3,4-Tetrahydro-5-quinolinecarboxylic acid ethyl ester; 5-(Ethoxycarbonyl)-1,2,3,4-tetrahydroquinoline; Quinoline-5-carboxylic acid, 1,2,3,4-tetrahydro-, ethyl ester
EINECS	Contact for details

Quality Control

Our 1,2,3,4-Tetrahydroquinoline-5-Carboxylic Acid Ethyl Ester is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong alkalis and incompatible organic solvents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.