Description

Ac-Phg(4-Oh)-Oet CAS NO 117785-07-6 is a protected derivative of the non-proteinogenic amino acid phenylglycine, specifically featuring an acetyl group and an ethyl ester. This compound is a crucial chiral building block and intermediate in advanced organic synthesis, particularly for the development of pharmaceuticals and bioactive molecules. It is essential for research and production in medicinal chemistry, serving scientists and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity, structurally defined intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in protease inhibitor and peptide-mimetic drug development.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce modified phenylglycine residues, influencing peptide stability and bioactivity.
• Medicinal Chemistry Research: Serves as a versatile building block for constructing compound libraries in drug discovery programs targeting various diseases.
• Agrochemical Synthesis: An intermediate in the production of advanced, chiral herbicides and plant growth regulators.
• Biochemical Tool Development: Employed in the design and synthesis of enzyme inhibitors, receptor ligands, and fluorescent probes for biochemical assays.
• Fine Chemical Production: Used in the multi-step synthesis of complex, high-value specialty chemicals and catalysts.

Basic Information

Product Name	Ac-Phg(4-Oh)-Oet
CAS No.	117785-07-6
Molecular Formula	C13H17NO4
Molecular Weight	251.28 g/mol
Synonyms	N-Acetyl-4-hydroxyphenylglycine ethyl ester; Ethyl N-acetyl-4-hydroxyphenylglycinate; Ac-PHG(4-OH)-OEt; (2R)-2-Acetamido-2-(4-hydroxyphenyl)acetic acid ethyl ester; (2S)-2-Acetamido-2-(4-hydroxyphenyl)acetic acid ethyl ester; N-Acetyl-4-hydroxy-DL-phenylglycine ethyl ester; 2-(Acetylamino)-2-(4-hydroxyphenyl)acetic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ac-Phg(4-Oh)-Oet is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure compliance with exacting standards for research and production use. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D- or L- isomer available)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.