Description

Fmoc-D-Bpa-Oh CAS NO 117666-97-4 is a high-purity, protected amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for the controlled incorporation of the photo-crosslinkable amino acid D-Bpa (D-4-benzoylphenylalanine) into peptide chains, enabling advanced structural and interaction studies. It is an essential building block for researchers and manufacturers in pharmaceutical R&D, proteomics, and bioconjugation, facilitating the development of novel therapeutics and diagnostic tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected derivative, it is a key monomer for the automated synthesis of peptides containing photo-activatable crosslinking sites.
• Photaffinity Labeling Probes: Used to create peptides and proteins with benzophenone moieties for studying protein-protein interactions, ligand-receptor binding, and mapping biological active sites.
• Bioconjugation and Chemical Biology: Serves as a precursor for generating photo-crosslinkable tags and functional handles on biomolecules for imaging, targeting, and therapeutic applications.
• Structural Biology Research: Enables the covalent capture of transient biomolecular complexes for analysis by techniques like mass spectrometry and X-ray crystallography.
• Drug Discovery Platforms: Integral to developing peptide-based drug candidates and high-throughput screening assays that utilize photaffinity crosslinking.
• Material Science & Smart Biomaterials: Incorporation into synthetic polymers or hydrogels to create light-responsive materials for controlled release or tissue engineering.

Basic Information

Product Name	Fmoc-D-Bpa-Oh
CAS No.	117666-97-4
Molecular Formula	C31H25NO5
Molecular Weight	491.53 g/mol
Synonyms	Fmoc-D-4-benzoylphenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-benzoyl-D-phenylalanine; Fmoc-D-4-Benzoyl-Phe-OH; Fmoc-D-Bpa-OH; N-Fmoc-D-4-benzoylphenylalanine; (2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[4-(phenylcarbonyl)phenyl]propanoic acid; D-4-Benzoylphenylalanine, N-Fmoc derivative
EINECS	Contact for details

Quality Control

Our Fmoc-D-Bpa-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment, chiral analysis to confirm stereochemical integrity, and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.