Description

1-(tert-Butoxycarbonyl)-1H-Pyrrole-2-Carboxylic Acid is a protected pyrrole derivative that serves as a crucial building block in organic synthesis. This compound is essential for the efficient construction of complex heterocyclic molecules, particularly in pharmaceutical research and development. It is primarily needed by fine chemical manufacturers and R&D laboratories engaged in the synthesis of active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, particularly those containing pyrrole or indole core structures.
• Peptide Mimetics & PROTACs: Used in the development of peptidomimetics and Proteolysis Targeting Chimeras (PROTACs) due to its carboxylic acid and protected amine functionalities.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with heterocyclic activity.
• Material Science: Employed in the research and production of organic semiconductors, conductive polymers, and advanced organic frameworks.
• Academic & Contract Research: A valuable reagent for methodological development in organic chemistry and for custom synthesis projects in CROs (Contract Research Organizations).
• Scale-up & Process Chemistry: Suitable for process optimization and kilogram-scale production under current Good Manufacturing Practice (cGMP) guidelines for advanced intermediates.

Basic Information

Item	Detail
Product Name	1-(tert-Butoxycarbonyl)-1H-Pyrrole-2-Carboxylic Acid
CAS No.	117657-40-6
Molecular Formula	C10H13NO4
Molecular Weight	211.21 g/mol
Synonyms	1-Boc-pyrrole-2-carboxylic acid; 1-(tert-Butoxycarbonyl)-2-pyrrolecarboxylic Acid; 1-N-Boc-pyrrole-2-carboxylic acid; 2-Carboxy-1H-pyrrole-1-carboxylic acid tert-butyl ester; 1H-Pyrrole-2-carboxylic acid, 1-[(1,1-dimethylethoxy)carbonyl]-; Boc-Pyrrole-2-COOH; tert-Butyl 2-carboxypyrrole-1-carboxylate; 1-Boc-2-pyrrolecarboxylic Acid
EINECS	Contact for details

Quality Control

Our 1-(tert-Butoxycarbonyl)-1H-Pyrrole-2-Carboxylic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system is designed to support cGMP compliance for advanced intermediate production, and we can accommodate customer-specific analytical requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.