Description

3-Quinolinecarboxylic Acid, 7-(3-Amino-1-Pyrrolidinyl)-8-Chloro-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound is a key synthetic precursor in the development of modern fluoroquinolone antibiotics, valued for its precise molecular structure which is critical for biological activity. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the synthesis of novel antibacterial agents and active pharmaceutical ingredients (APIs).

Application

This specialized intermediate is designed for high-value synthesis in regulated environments. Its primary and related applications include:

• Active Pharmaceutical Ingredient (API) Synthesis: A critical building block in the production of advanced fluoroquinolone antibiotic compounds.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the discovery and optimization of new antibacterial drug candidates.
• Process Chemistry & Scale-Up: Serves as a key intermediate in pilot plant and commercial manufacturing processes for antibiotic APIs.
• Reference Standard: Can be utilized as a high-purity standard for analytical method development and quality control in pharmaceutical analysis.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of pharmaceutical substances.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 7-(3-Amino-1-Pyrrolidinyl)-8-Chloro-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-
CAS No.	117404-52-1
Molecular Formula	C₁₇H₁₈ClFN₄O₃
Molecular Weight	380.80 g/mol
Synonyms	7-(3-Aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 8-Chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid intermediate; Gatifloxacin intermediate; AM-1155 intermediate; (±)-1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid related compound; 1-Cyclopropyl-6-fluoro-7-(3-aminopyrrolidin-1-yl)-8-chloro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of this pharmaceutical intermediate adheres to stringent quality management systems. Each batch is manufactured under controlled conditions and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), related substances, residual solvents, and chiral purity are provided with every shipment. We support development and commercial projects requiring compliance with cGMP, ICH Q7 guidelines, and relevant pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in original packaging under inert atmosphere if necessary to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.