Description

3-(4-Methylphenyl)-3-[(2,2,2-Trifluoroacetyl)Amino]Propanoic Acid is a specialized fluorinated organic building block of significant interest in advanced synthetic chemistry. Its core value lies in its unique molecular architecture, which incorporates both a trifluoroacetyl-protected amino group and a carboxylic acid moiety, making it a versatile intermediate for constructing complex molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly those requiring the metabolic stability and lipophilicity imparted by the trifluoromethyl group.

Application

• Pharmaceutical Intermediate: Key synthon in the research and development of new drug candidates, especially protease inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity and environmental persistence.
• Peptidomimetics Research: Serves as a non-natural amino acid derivative for constructing peptide analogs with improved stability and binding affinity.
• Material Science Precursor: Potential building block for specialty polymers and liquid crystals that require fluorinated components for specific thermal or optical properties.
• Chemical Biology Probes: Utilized in the development of activity-based probes and inhibitors for studying enzyme function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	3-(4-Methylphenyl)-3-[(2,2,2-Trifluoroacetyl)Amino]Propanoic Acid
CAS No.	117291-15-3
Molecular Formula	C12H12F3NO3
Molecular Weight	275.22 g/mol
Synonyms	3-(p-Tolyl)-3-[(2,2,2-trifluoroacetyl)amino]propanoic acid; 3-(4-Methylphenyl)-3-[(trifluoroacetyl)amino]propionic acid; N-(Trifluoroacetyl)-3-amino-3-(4-methylphenyl)propanoic acid; β-[(Trifluoroacetyl)amino]-4-methylbenzenepropanoic acid; 117291-15-3; TFA-Protected 3-Amino-3-(p-tolyl)propanoic Acid
EINECS	Contact for details

Quality Control

Our 3-(4-Methylphenyl)-3-[(2,2,2-Trifluoroacetyl)Amino]Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. For projects requiring specific regulatory support, we can discuss compliance with relevant guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.