Description

2-Pyrrolidinecarbothioamide, Monohydrochloride, (R)- (9Ci) is a high-purity chiral building block and pharmaceutical intermediate. This compound is of significant value for its role in the synthesis of enantiomerically pure molecules, particularly in medicinal chemistry research and development. It is primarily needed by pharmaceutical companies, biotechnology firms, and advanced research institutions engaged in drug discovery, process chemistry, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for neurological and metabolic disorders.
• Asymmetric Synthesis: Used as a precursor or catalyst ligand in stereoselective synthesis to construct complex molecules with high enantiomeric purity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization for novel drug candidates.
• Process Chemistry Development: Serves as a starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Biochemical Research: Potential use as a probe or inhibitor in enzymatic studies due to its thioamide functional group.
• Custom Synthesis: A building block for contract research organizations (CROs) and CDMOs specializing in custom chemical synthesis.

Basic Information

Product Name	2-Pyrrolidinecarbothioamide, Monohydrochloride, (R)- (9Ci)
CAS No.	117175-42-5
Molecular Formula	C5H11ClN2S
Molecular Weight	166.67 g/mol
Synonyms	(R)-2-Pyrrolidinecarbothioamide Hydrochloride; (R)-Pyrrolidine-2-carbothioamide Hydrochloride; (R)-2-Aminocarbonylpyrrolidine-1-thioamide Hydrochloride; (R)-PCA Hydrochloride; (R)-Proline Thioamide Hydrochloride; (R)-2-Carbamoylpyrrolidine Thioamide Hydrochloride; (R)-2-Thiocarbamoylpyrrolidine Hydrochloride
EINECS	Contact for details

Quality Control

Our 2-Pyrrolidinecarbothioamide, Monohydrochloride, (R)- (9Ci) is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (assay), enantiomeric excess, and related substances is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.