Description

Fmoc-Nh(Ch2)4Nh2 Hcl is a specialized, high-purity Fmoc-protected diamine building block, essential for the synthesis of complex peptides and other bioactive molecules. This compound is critical for researchers and manufacturers requiring precise control over molecular structure and sequence in solid-phase peptide synthesis (SPPS). It is primarily utilized by pharmaceutical R&D teams, biotech companies, and fine chemical suppliers engaged in developing novel therapeutics, diagnostic agents, and advanced materials.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for introducing a lysine-like side chain with a free amino group after deprotection, enabling the construction of branched peptides and peptide dendrimers.
• Linker and Spacer Chemistry: Used to incorporate a flexible, hydrophilic tetra-methylene spacer (C4) between functional groups in bioconjugation and the development of drug delivery systems.
• Combinatorial Library Development: Serves as a versatile building block for generating diverse compound libraries for high-throughput screening in drug discovery.
• Synthesis of Peptide Mimetics: Facilitates the creation of peptidomimetics and constrained peptides by providing a modifiable amine handle for further chemical elaboration.
• Material Science: Employed in the synthesis of functionalized polymers and surfaces where precise amine placement is required.

Basic Information

Product Name	Fmoc-Nh(Ch2)4Nh2 Hcl
CAS No.	117048-49-4
Molecular Formula	C₂₀H₂₅ClN₂O₂
Molecular Weight	360.88 g/mol
Synonyms	Fmoc-Dab(Boc)-OH (precursor related); Nα-Fmoc-Nδ-4-aminobutyl-L-2,4-diaminobutyric acid hydrochloride; Fmoc-L-Dab(4-NH2)-OH · HCl; Fmoc-4-Aminobutylamine hydrochloride; 1-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-4-aminobutane hydrochloride; N-(9-Fluorenylmethoxycarbonyl)-1,4-diaminobutane hydrochloride; Fmoc-1,4-diaminobutane HCl
EINECS	Contact for details

Quality Control

Our Fmoc-Nh(Ch2)4Nh2 Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and moisture content. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and cGMP-grade manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. Due to its hygroscopic (moisture-sensitive) nature, the container should be sealed under an inert atmosphere after opening and allowed to equilibrate to room temperature before use to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.