Description

D-Fructose (2-13C) is a stable isotope-labeled analog of the natural monosaccharide, where the carbon atom at the 2-position is enriched with the carbon-13 isotope. This compound is essential for advanced metabolic research and analytical applications, providing a critical tracer for studying carbohydrate metabolism, flux analysis, and biochemical pathways. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic manufacturers engaged in isotope dilution mass spectrometry (IDMS), nuclear magnetic resonance (NMR) spectroscopy, and the development of internal standards for clinical assays.

Application

• Metabolic Pathway Tracing: Used as a 13C-labeled tracer in in vitro and in vivo studies to elucidate fructose metabolism, glycolysis, and the pentose phosphate pathway.
• Quantitative Mass Spectrometry: Serves as a high-purity internal standard for the accurate quantification of endogenous D-fructose in biological samples (e.g., plasma, urine, tissue) via LC-MS/MS or GC-MS.
• NMR Spectroscopy: Enables detailed structural and dynamic studies of carbohydrate-protein interactions and metabolic flux analysis (13C-NMR).
• Stable Isotope-Labeled Standards (SILS): Critical for developing certified reference materials (CRMs) and calibrators in clinical chemistry and food analysis.
• Pharmaceutical Research: Employed in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of fructose-containing compounds or related drug candidates.
• Nutritional Science: Used in research investigating fructose absorption, utilization, and its role in metabolic disorders.

Basic Information

Product Name	D-Fructose (2-13C)
CAS No.	117013-19-1
Molecular Formula	C6H12O6 (with 13C at position 2)
Molecular Weight	181.16 g/mol (for 13C1 isotopologue)
Synonyms	(2-13C)-D-Fructose; D-(-)-Fructose-2-13C; Fructose-2-13C; Levulose-2-13C; Fruit Sugar-2-13C; (3S,4R,5R)-1,3,4,5,6-Pentahydroxyhexan-2-one-2-13C; β-D-Fructopyranose-2-13C; β-D-(-)-Fructose-2-13C
EINECS	Contact for details

Quality Control

Our D-Fructose (2-13C) is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity for research and diagnostic applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment (atom % 13C), chemical purity, and specific optical rotation. We adhere to relevant guidelines for the production of stable isotope-labeled compounds.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Isotopic Enrichment (Atom % 13C)	≥ 99% (Position 2)
Chemical Purity (HPLC)	≥ 98.0%
Specific Optical Rotation	-91° to -95° (c=2, H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.