Description

Methyl 4-(Bromomethyl)Nicotinate CAS NO 116986-11-9 is a versatile and high-purity brominated nicotinate derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the reactive bromomethyl group, which facilitates efficient carbon-carbon bond formation and functional group interconversions under mild conditions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex drug candidates, particularly those containing nicotinic acid or pyridine cores, for therapeutic areas like oncology and neurology.
• Agrochemical Synthesis: Used in constructing novel pesticide and herbicide molecules, leveraging the pyridine moiety for bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological processes and protein interactions.
• Material Science Research: A building block for synthesizing functionalized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromomethyl group acts as an effective handle for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille).

Basic Information

Product Name	Methyl 4-(Bromomethyl)Nicotinate
CAS No.	116986-11-9
Molecular Formula	C8H8BrNO2
Molecular Weight	230.06 g/mol
Synonyms	4-(Bromomethyl)nicotinic acid methyl ester; Methyl 4-(bromomethyl)pyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 4-(bromomethyl)-, methyl ester; Nicotinic acid, 4-(bromomethyl)-, methyl ester
EINECS	Contact for details

Quality Control

Every batch of Methyl 4-(Bromomethyl)Nicotinate is manufactured and tested under strict quality management systems. We guarantee high chemical purity and consistency, supported by comprehensive analytical documentation. A detailed Certificate of Analysis (COA) providing results for identity, assay, and impurity profiles (typically by HPLC, GC, NMR) is supplied with each shipment to ensure it meets your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.