Description

(2,3-Difluorophenyl)Hydrazine is a specialized aromatic hydrazine derivative that serves as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms on the phenyl ring, which can dramatically influence the electronic properties, metabolic stability, and binding affinity of final target molecules. This high-purity intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for constructing heterocyclic scaffolds and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides where the difluorophenyl moiety enhances biological activity and environmental profile.
• Material Science Research: Employed in the creation of specialized polymers, liquid crystals, and organic electronic materials due to its ability to modify molecular conformation and intermolecular interactions.
• Chemical Biology & Proteomics: Acts as a reactive handle for bioconjugation and the development of chemical probes and affinity tags.
• Dye and Pigment Industry: Serves as a starting material for synthesizing complex heterocyclic dyes and functional colorants.

Basic Information

Product Name	(2,3-Difluorophenyl)Hydrazine
CAS No.	116681-58-4
Molecular Formula	C6H6F2N2
Molecular Weight	144.12 g/mol
Synonyms	2,3-Difluorophenylhydrazine; 1-(2,3-Difluorophenyl)hydrazine; (2,3-Difluorophenyl)hydrazine; Hydrazine, (2,3-difluorophenyl)-; 2,3-DFPH
EINECS	Contact for details

Quality Control

Our (2,3-Difluorophenyl)Hydrazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications. Our quality commitment supports applications requiring GMP-grade starting materials and aligns with ICH guidelines for impurity profiling.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. This material is easily oxidized and moisture-sensitive; allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.