Description

(2R)-2-Boc-Amino-3-Phenylsulfonyl-1-(2-Tetrahydropyranyloxy)Propane is a high-purity, chiral organic building block essential for advanced pharmaceutical synthesis. This compound is valued for its role as a key intermediate in the development of complex, biologically active molecules, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of novel drug candidates, particularly in the fields of peptide mimetics and protease inhibitors.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the research and development of new active pharmaceutical ingredients (APIs).
• Peptidomimetic Synthesis: Used to construct non-peptide scaffolds that mimic the structure and function of natural peptides for drug discovery.
• Protease Inhibitor Development: Serves as a building block for compounds targeting various protease enzymes.
• Asymmetric Synthesis: Employed in stereoselective chemical reactions to introduce specific chiral centers into complex molecules.
• Medicinal Chemistry Research: A valuable tool for structure-activity relationship (SAR) studies and lead optimization in drug design.
• Custom Synthesis: Used by contract research and manufacturing organizations (CROs/CMOs) for bespoke chemical synthesis projects.

Basic Information

Product Name	(2R)-2-Boc-Amino-3-Phenylsulfonyl-1-(2-Tetrahydropyranyloxy)Propane
CAS No.	116611-45-1
Molecular Formula	C19H29NO6S
Molecular Weight	399.50 g/mol
Synonyms	1-[(2R)-2-[(tert-Butoxycarbonyl)amino]-3-(phenylsulfonyl)propoxy]tetrahydro-2H-pyran; (2R)-2-[(tert-Butoxycarbonyl)amino]-3-(phenylsulfonyl)-1-(tetrahydro-2H-pyran-2-yloxy)propane; Boc-D-Phe(SO2Ph)-OTHP; N-Boc-3-phenylsulfonyl-D-alanine THP ester; tert-Butyl ((2R)-1-((tetrahydro-2H-pyran-2-yl)oxy)-3-(phenylsulfonyl)propan-2-yl)carbamate
EINECS	Contact for details

Quality Control

Our (2R)-2-Boc-Amino-3-Phenylsulfonyl-1-(2-Tetrahydropyranyloxy)Propane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity verification, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.