Description

n-Tritylglycine Hydrazide is a specialized trityl-protected amino acid derivative that serves as a critical building block in advanced organic synthesis. Its primary value lies in its role as a versatile intermediate for the preparation of peptides and other bioactive molecules, where the trityl group offers orthogonal protection strategies. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors engaged in developing novel therapeutic agents and complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis as a protected glycine derivative.
• Bioconjugation: Serves as a linker or spacer molecule for attaching functional groups to biomolecules.
• Chemical Biology Research: Employed in the development of enzyme inhibitors, probes, and other research tools.
• Fine Chemical Synthesis: Intermediate for creating complex organic molecules with specific chiral centers or functional groups.
• Protecting Group Strategy: The trityl moiety is utilized for the temporary protection of amino groups during multi-step synthetic sequences.

Basic Information

Product Name	n-Tritylglycine Hydrazide
CAS No.	116435-38-2
Molecular Formula	C21H21N3O
Molecular Weight	331.41 g/mol
Synonyms	2-[(Triphenylmethyl)amino]acetohydrazide; Glycine, N-(triphenylmethyl)-, hydrazide; Trityl-Gly-NHNH2; N-Tritylglycine hydrazide; N-(Triphenylmethyl)glycine hydrazide; (Triphenylmethylamino)acetic acid hydrazide; Nα-Tritylglycine hydrazide
EINECS	Contact for details

Quality Control

Our n-Tritylglycine Hydrazide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized and should be handled and stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.