Description

5-Fluoro-3,4-Dihydroquinolin-2(1H)-One is a high-purity fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound serves as a critical intermediate for the development of novel pharmaceutical agents and agrochemicals, where its unique scaffold enables the introduction of key structural motifs. It is primarily sought after by research institutions and industrial R&D departments focused on medicinal chemistry, particularly in the synthesis of complex molecules targeting central nervous system and oncological pathways.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for neurological and oncological targets.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and pesticides, leveraging the biological activity of the fluorinated quinolinone core.
• Material Science Precursor: Serves as a building block for advanced organic materials, including ligands for catalysis and components for organic electronics.
• Academic & Contract Research: Essential for method development and exploratory synthesis in university laboratories and contract research organizations (CROs).
• Fluorine Chemistry Studies: A valuable substrate for investigating fluorination effects and structure-activity relationships (SAR) in medicinal chemistry programs.

Basic Information

Product Name	5-Fluoro-3,4-Dihydroquinolin-2(1H)-One
CAS No.	116434-95-8
Molecular Formula	C9H8FNO
Molecular Weight	165.17 g/mol
Synonyms	5-Fluoro-1,2,3,4-tetrahydroquinolin-2-one; 5-Fluoro-3,4-dihydro-2(1H)-quinolinone; 5-Fluoro-1,2,3,4-tetrahydro-2-quinolone; 5-Fluoro-2-oxo-1,2,3,4-tetrahydroquinoline; 5-FTDQ; 5-Fluoro-tetrahydro-2-quinolone
EINECS	Contact for details

Quality Control

Our production of 5-Fluoro-3,4-Dihydroquinolin-2(1H)-One adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep the container sealed to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.