Description

(1R,4R)-2,5-Diazabicyclo[2.2.1]heptane is a high-purity, chiral bicyclic diamine building block of significant importance in modern synthetic chemistry. Its rigid, three-dimensional scaffold and dual nitrogen functionalities make it a versatile intermediate for constructing complex molecular architectures, particularly in pharmaceutical research. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in asymmetric synthesis and ligand design.

Application

• Pharmaceutical Intermediate: A key chiral scaffold for the synthesis of active pharmaceutical ingredients (APIs), especially in neurology and oncology drug discovery.
• Asymmetric Catalyst Ligand: Used to construct chiral ligands for transition metal catalysis, enabling enantioselective transformations.
• Agrochemical Synthesis: Serves as a building block for developing novel, chiral crop protection agents with enhanced efficacy.
• Organocatalyst: Functions as a base or nucleophile in organocatalytic cycles for carbon-carbon and carbon-heteroatom bond formation.
• Chelating Agent: Its diamine structure allows it to act as a chelator for metal ions in various analytical or material science applications.
• Polymer Modification: Incorporated into polymer backbones to impart rigidity, chirality, or basicity to specialty polymers.

Basic Information

Product Name	(1R,4R)-2,5-Diazabicyclo[2.2.1]heptane
CAS No.	116183-84-7
Molecular Formula	C5H10N2
Molecular Weight	98.15 g/mol
Synonyms	(1R,4R)-2,5-Diazabicyclo[2.2.1]heptane; (1R,4R)-2,5-Diazanorbornane; endo-2,5-Diazabicyclo[2.2.1]heptane; (1R,4R)-1,4-Diaminocyclopentane-2,3-dimethylene; (1R,4R)-Bicyclo[2.2.1]heptane-2,5-diamine; (1R,4R)-2,5-DABCO heptane; Chiral DABCO derivative
EINECS	Contact for details

Quality Control

Our (1R,4R)-2,5-Diazabicyclo[2.2.1]heptane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing including chiral HPLC, NMR, and GC/MS to ensure identity, purity, and enantiomeric excess meet stringent specifications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to cGMP compliance and traceability ensures reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.