Description

(3R)-(-)-3-Aminopyrrolidine Dihydrochloride is a high-purity chiral building block essential for the synthesis of complex pharmaceutical intermediates. Its defined stereochemistry is critical for creating active pharmaceutical ingredients (APIs) with specific biological activity, ensuring efficacy and safety in final drug formulations. This compound is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for developing novel therapeutics and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of drug candidates, particularly for central nervous system (CNS) and antiviral applications.
• API Synthesis: Used in the construction of complex molecular scaffolds for active pharmaceutical ingredients requiring a pyrrolidine-based chiral amine.
• Agrochemical Research: Serves as a building block for developing novel pesticides and herbicides with enhanced stereoselective activity.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands for asymmetric catalysis and metal complexes.
• Peptidomimetics: Integral for designing and synthesizing peptidomimetic compounds in medicinal chemistry programs.
• Chemical Biology Probes: Used to create molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	(3R)-(-)-3-Aminopyrrolidine Dihydrochloride
CAS No.	116183-81-4
Molecular Formula	C4H10N2 · 2HCl
Molecular Weight	167.06 g/mol
Synonyms	(R)-(-)-3-Aminopyrrolidine Dihydrochloride; (3R)-3-Aminopyrrolidine Hydrochloride; (R)-3-Aminopyrrolidine Dihydrochloride; (R)-3-Pyrrolidinamine Dihydrochloride; (3R)-3-Aminopyrrolidine Dihydrochloride; (R)-3-Amino-tetrahydro-pyrrole Dihydrochloride; (R)-3-APD Dihydrochloride; (R)-3-AP·2HCl
EINECS	Contact for details

Quality Control

Our (3R)-(-)-3-Aminopyrrolidine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.