Description

1-tert-Butyl-6-Fluoro-1,4-Dihydro-4-Oxo-7-Piperazino-1,8-Naphthyridine-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is a key structural motif in the development of novel antibacterial agents, particularly within the quinolone and naphthyridine antibiotic classes. It is essential for R&D chemists and manufacturers in the pharmaceutical industry engaged in the synthesis of next-generation active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel quinolone and naphthyridine-based antibacterial drugs.
• Antibiotic Research & Development: Used in medicinal chemistry programs to develop new compounds targeting bacterial DNA gyrase and topoisomerase IV.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a precursor in the multi-step manufacturing process of complex antibiotic APIs.
• Chemical Reference Standard: Employed as a high-purity standard in analytical laboratories for method development, validation, and quality control testing.
• Academic & Contract Research: Utilized in university and CRO settings for pharmacological studies and structure-activity relationship (SAR) investigations.
• Process Chemistry Optimization: Applied in scaling up and optimizing synthetic routes for cost-effective and robust API production.

Basic Information

Product Name	1-tert-Butyl-6-Fluoro-1,4-Dihydro-4-Oxo-7-Piperazino-1,8-Naphthyridine-3-Carboxylic Acid
CAS No.	116162-91-5
Molecular Formula	C₁₇H₂₁FN₄O₃
Molecular Weight	348.38 g/mol
Synonyms	1-(1,1-Dimethylethyl)-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid; 7-Piperazinyl-1-tert-butyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid; 1-tert-Butyl-6-fluoro-7-piperazin-1-yl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid; TBFPONCA; 1,8-Naphthyridine-3-carboxylic acid, 1-(1,1-dimethylethyl)-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-
EINECS	Contact for details

Quality Control

Our 1-tert-Butyl-6-Fluoro-1,4-Dihydro-4-Oxo-7-Piperazino-1,8-Naphthyridine-3-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for pharmaceutical R&D and manufacturing. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.