Description

2H-Furo[3,2-B]Pyrrol-2-Ol, 4-Acetylhexahydro-, [2S-(2Alpha,3Aalpha,6Aalpha)]- (9Ci) is a high-purity, stereochemically defined heterocyclic compound of significant interest in advanced organic synthesis. This specialized chiral building block is valued for its unique fused furan-pyrrole structure, which serves as a critical precursor in the development of novel pharmacologically active molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of complex natural product analogs.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-infective drug candidates.
• Medicinal Chemistry Research: Used as a scaffold or building block for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric reactions to introduce complex stereocenters into target molecules.
• Natural Product Synthesis: Acts as a precursor in the total or semi-synthesis of complex natural products containing fused heterocyclic motifs.
• Process Chemistry Development: Utilized in scaling up synthetic routes from laboratory to pilot plant scale for potential commercial manufacturing.
• Chemical Biology Probes: Can be functionalized to create molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	2H-Furo[3,2-B]Pyrrol-2-Ol, 4-Acetylhexahydro-, [2S-(2Alpha,3Aalpha,6Aalpha)]- (9Ci)
CAS No.	116050-86-3
Molecular Formula	C8H11NO3
Molecular Weight	169.18 g/mol
Synonyms	4-Acetylhexahydro-2H-furo[3,2-b]pyrrol-2-ol, (2S,3aR,6aR)-rel-; Hexahydro-4-acetyl-2H-furo[3,2-b]pyrrol-2-ol; (2S,3aR,6aR)-4-Acetylhexahydro-2H-furo[3,2-b]pyrrol-2-ol; Furo[3,2-b]pyrrol-2-ol derivative; Chiral fused heterocyclic alcohol; CAS 116050-86-3.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and purity for critical research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. Quality assurance is managed under a cGMP-compliant quality management system, with analytical methods validated to ICH guidelines where applicable to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.