Description

(R)-(-)-Glycidyl Nosylate is a high-value chiral building block and electrophilic glycidylating agent. This compound is essential for the stereoselective synthesis of complex molecules, enabling the introduction of an epoxide moiety with defined stereochemistry. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and fine chemical industries for the production of active pharmaceutical ingredients (APIs), advanced intermediates, and novel materials.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of β-blockers, antiviral agents, and other enantiomerically pure drugs.
• Asymmetric Synthesis: Used as an electrophile in nucleophilic ring-opening reactions to construct chiral 1,2-difunctionalized compounds.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric catalysis.
• Material Science Research: Employed in the synthesis of chiral polymers and advanced functional materials with specific optical properties.
• Chemical Biology Probes: Useful for the selective modification of biomolecules to study protein function and interactions.
• Process Chemistry: Scalable intermediate for the development of efficient, stereocontrolled manufacturing routes for target molecules.

Basic Information

Product Name	(R)-(-)-Glycidyl Nosylate
CAS No.	115314-17-5
Molecular Formula	C9H9NO5S
Molecular Weight	243.24 g/mol
Synonyms	(R)-Glycidyl 4-Nitrobenzenesulfonate; (R)-(-)-Glycidyl 4-Nitrobenzenesulfonate; (2R)-(-)-Glycidyl 4-Nitrobenzenesulfonate; (R)-Oxiran-2-ylmethyl 4-nitrobenzenesulfonate; (R)-Glycidyl p-Nosylate; (R)-Glycidyl Nosylate; (R)-Epoxypropyl p-Nosylate; (R)-1,2-Epoxy-3-((4-nitrophenyl)sulfonyloxy)propane
EINECS	Contact for details

Quality Control

Our (R)-(-)-Glycidyl Nosylate is manufactured under strict quality control protocols to ensure high chemical and enantiomeric purity, meeting the stringent requirements of research and development. Each batch is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.